Aging is inevitable, but what if we could slow it down, reverse some effects, and extend our healthspan? Thanks to cutting-edge research in longevity science, a growing number of drugs and supplements are showing promise in boosting cellular repair, reducing inflammation, and even extending lifespan. In 2025, the anti-aging space is booming with breakthroughs, from pharmaceuticals that mimic calorie restriction to natural compounds that support mitochondrial function.
But with so many options on the market, how do you know what works and what’s just hype? This guide breaks down the top 12 anti-aging drugs and supplements that are making waves this year.
Disclaimer: This article is for informational purposes only and should not be considered medical advice. Always consult a healthcare professional before starting any new supplement or medication, especially those that impact aging and longevity.
1️⃣ Rapamycin – The Most Promising Longevity Drug
Originally developed as an immunosuppressant for organ transplant patients, rapamycin has become one of the most studied drugs in the longevity field. It works by inhibiting the mTOR pathway, which plays a key role in aging and cellular metabolism. Research suggests that periodic low doses of rapamycin can extend lifespan in mice and improve various markers of aging in humans.
Why it’s trending in 2025:
- Slows down cellular aging by reducing excess cell growth.
- Enhances autophagy, the body’s natural cellular cleanup process.
- May reduce inflammation and improve immune function in older adults.
Potential downsides:
- Can suppress the immune system if taken in high doses.
- Long-term effects in humans are still being studied.
Best for: Those looking for a science-backed pharmaceutical approach to longevity with medical supervision.
2️⃣ NAD+ Boosters – Cellular Energy and DNA Repair
NAD+ (nicotinamide adenine dinucleotide) is a coenzyme essential for energy production and DNA repair. Levels of NAD+ decline with age, leading to reduced cellular function and increased susceptibility to age-related diseases. Supplements like NMN (nicotinamide mononucleotide) and NR (nicotinamide riboside) help replenish NAD+ levels and have gained popularity for their potential anti-aging benefits.
Why it’s trending in 2025:
- Supports mitochondrial function and cellular energy production.
- Helps activate sirtuins, proteins linked to longevity.
- May improve muscle function, cognitive health, and metabolic efficiency.
Potential downsides:
- Research on long-term effects in humans is still ongoing.
- Some NAD+ precursors may be more effective than others.
Best for: People looking for a non-prescription supplement that targets aging at the cellular level.
3️⃣ Metformin – The Diabetes Drug with Anti-Aging Benefits
Metformin is a widely used diabetes drug that has caught the attention of longevity researchers due to its potential life-extending effects. It works by improving insulin sensitivity, reducing inflammation, and mimicking some of the benefits of calorie restriction. Several studies suggest that metformin users have lower rates of age-related diseases such as cancer, cardiovascular disease, and cognitive decline.
Why it’s trending in 2025:
- May lower the risk of age-related diseases like cancer and Alzheimer’s.
- Reduces inflammation and oxidative stress, both linked to aging.
- Helps regulate blood sugar levels and metabolic health.
Potential downsides:
- Can cause digestive issues in some people.
- Requires a prescription and medical supervision.
Best for: Individuals interested in a pharmaceutical option with strong data on metabolic and longevity benefits.
4️⃣ Fisetin – The Senescent Cell Destroyer
Fisetin is a flavonoid found in strawberries, apples, and onions that has gained attention for its ability to clear out senescent cells. These are aging cells that no longer function properly and contribute to chronic inflammation, a major driver of aging and age-related diseases. Unlike some other senolytics, fisetin is available as an over-the-counter supplement and has shown promising results in animal studies.
Why it’s trending in 2025:
- Helps eliminate senescent cells, reducing inflammation.
- May improve brain function and protect against neurodegenerative diseases.
- Supports skin health and may slow visible aging.
Potential downsides:
- Bioavailability is low, so it may need to be paired with fat or other absorption enhancers.
- Human clinical trials are still ongoing to confirm its long-term effects.
Best for: Those looking for a natural way to target cellular aging and reduce inflammation.
5️⃣ Spermidine – The Autophagy Activator
Spermidine is a naturally occurring compound found in foods like wheat germ, soybeans, and mushrooms. It is known for its ability to stimulate autophagy, the process by which cells break down and recycle damaged components. This function is crucial for longevity, as inefficient autophagy leads to the buildup of cellular waste and contributes to aging.
Why it’s trending in 2025:
- Supports autophagy, improving cellular maintenance and repair.
- May enhance brain health and cognitive longevity.
- Has shown potential in extending lifespan in animal studies.
Potential downsides:
- Natural sources contain varying amounts, making dosage inconsistent.
- Human studies are promising but still in early stages.
Best for: Those looking to naturally boost cellular cleanup processes and slow age-related decline.
6️⃣ Quercetin – The Longevity Antioxidant
Quercetin is a powerful antioxidant and flavonoid found in apples, onions, and capers. It has gained popularity as a senolytic, meaning it helps remove dysfunctional aging cells from the body. It also has anti-inflammatory, antiviral, and cardiovascular benefits, making it a widely used supplement in longevity circles.
Why it’s trending in 2025:
- Works as a senolytic, helping clear out aging cells.
- Has strong anti-inflammatory and immune-boosting properties.
- May support heart health by improving circulation and reducing oxidative stress.
Potential downsides:
- Works best when combined with other senolytics like fisetin.
- Some formulations have low bioavailability, requiring pairing with fat or other absorption enhancers.
Best for: Individuals seeking a multi-functional supplement with anti-aging, cardiovascular, and immune benefits.
7️⃣ Resveratrol – The Anti-Aging Compound in Red Wine
Resveratrol is a polyphenol found in grapes, red wine, and berries that has been linked to longevity and disease prevention. It is known for activating sirtuins, proteins associated with cellular repair and lifespan extension. Some studies suggest it mimics the effects of calorie restriction, which has long been linked to increased longevity.
Why it’s trending in 2025:
- Activates sirtuins, which play a role in longevity.
- Has strong anti-inflammatory and antioxidant properties.
- May protect against neurodegenerative diseases like Alzheimer’s.
Potential downsides:
- The amount found in red wine is too low to have significant effects.
- Some studies question its bioavailability and effectiveness in humans.
Best for: Those looking for a natural antioxidant with potential longevity benefits.
8️⃣ Alpha-Ketoglutarate (AKG) – Cellular Fuel for Longevity
Alpha-ketoglutarate is a key molecule in cellular metabolism that declines with age. It plays a crucial role in energy production, collagen synthesis, and maintaining healthy mitochondria. Studies suggest that supplementing with AKG can slow age-related decline and promote overall vitality.
Why it’s trending in 2025:
- Supports mitochondrial function and energy metabolism.
- May help maintain bone and muscle health as we age.
- Has been linked to lifespan extension in animal studies.
Potential downsides:
- Research in humans is still limited, though early results are promising.
- Different formulations may have varying levels of effectiveness.
Best for: Those looking to improve energy levels and metabolic health as they age.
9️⃣ Collagen Peptides – Skin, Joints, and Longevity Support
Collagen is the most abundant protein in the body, but its production declines with age, leading to wrinkles, joint pain, and reduced skin elasticity. Supplementing with collagen peptides provides the amino acids needed to maintain healthy skin, hair, nails, and connective tissues.
Why it’s trending in 2025:
- Supports skin elasticity and hydration, reducing wrinkles.
- Helps maintain joint health and prevent age-related stiffness.
- May aid in gut health and digestion.
Potential downsides:
- Effectiveness varies depending on the type of collagen used.
- Some brands contain additives or lower-quality sources.
Best for: Those looking to maintain youthful skin, strong joints, and overall structural health.
🔟 Coenzyme Q10 (CoQ10) – The Mitochondrial Energizer
CoQ10 is a naturally occurring antioxidant that plays a vital role in mitochondrial energy production. As we age, CoQ10 levels decline, leading to reduced cellular energy and increased oxidative stress. Supplementing with CoQ10 has been shown to improve heart health, brain function, and overall vitality.
Why it’s trending in 2025:
- Supports mitochondrial energy production, reducing fatigue.
- Protects against oxidative damage linked to aging.
- May improve heart health and cognitive function.
Potential downsides:
- Some formulations have low bioavailability and need to be taken with fat.
- Effects may take weeks or months to become noticeable.
Best for: Individuals looking to support energy levels, heart health, and overall cellular function.
1️⃣1️⃣ Astaxanthin – The Super Antioxidant
Astaxanthin is a powerful carotenoid antioxidant found in algae, salmon, and krill that has been linked to numerous anti-aging benefits. It is known for protecting skin from UV damage, reducing inflammation, and improving cardiovascular health. Some research suggests it may even enhance endurance and muscle recovery.
Why it’s trending in 2025:
- One of the most potent natural antioxidants available.
- Protects skin from sun damage and reduces wrinkles.
- May improve brain and heart health by reducing oxidative stress.
Potential downsides:
- Natural sources like wild salmon contain small amounts, requiring supplementation for higher doses.
- Some lower-quality supplements may not provide pure astaxanthin.
Best for: Those looking for a natural way to protect their skin, brain, and heart from oxidative stress.
1️⃣2️⃣ Taurine – The New Longevity Breakthrough
Taurine is an amino acid that plays a crucial role in cellular function, metabolism, and neurological health. Recent studies have suggested that taurine levels decline significantly with age, and supplementing with taurine may help improve longevity, muscle function, and cognitive performance.
Why it’s trending in 2025:
- May slow aging by reducing cellular damage.
- Supports brain health and may reduce the risk of neurodegenerative diseases.
- Helps maintain muscle function and endurance in aging individuals.
Potential downsides:
- Research is still emerging on long-term human benefits.
- Some energy drinks contain taurine, but often in combination with unhealthy additives.
Best for: Individuals looking to support overall longevity, brain function, and muscle health.
The search for longevity is more exciting than ever, with new research uncovering powerful drugs and supplements that may help slow aging, improve cellular function, and extend healthspan. While some of these compounds are still being studied, others have strong scientific backing and are already making a difference in the lives of those focused on aging well.
